Revue: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451247 |
ISSN: | 1984-8250 |
Autores: | Menotti, Vinicius Stela1 Scanferla, Deborah Thais Palma1 Oliveira, Kleber Ota de1 Fratucci, Gabriela Felber2 Alves, Gessé de Souza2 Bando, Erika2 Nerilo, Samuel Botião2 Oliveira, Magda Lúcia Félix de3 Machinski, Miguel2 Mossini, Simone Aparecida Galerani1 |
Instituciones: | 1Universidade Estadual de Maringa, Programa de Pos-Graduacao em Biociencias e Fisiopatologia, Maringa, Parana. Brasil 2Universidade Estadual de Maringa, Departamento de Ciencias Basicas da Saude, Maringa, Parana. Brasil 3Universidade Estadual de Maringa, Programa de Pos-Graduacao em Enfermagem, Maringa, Parana. Brasil |
Año: | 2020 |
Volumen: | 56 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Aplicado, descriptivo |
Resumen en inglés | The present study describes a method for simultaneous analysis of cocaine, benzoylecgonine and cocaethylene in urine samples. After solid phase extraction, Gas Chromatography-Mass Spectrometry was used for identification and quantification. The calibration curves were linear at 20 - 3000 ng/mL, r2 0.9997 for benzoylecgonine, 15 - 2000 ng/mL, r2 0.9985 and r2 0.9993 for cocaine and cocaethylene, respectively. Accuracy values: cocaine: 93,5 - 102,1%; benzoylecgonine: 97,5 - 104,8%; cocaethylene: 90,6 - 101,5%. Precision values: cocaine: C.V 5,4 - 14,6%; benzoylecgonine: C.V 7,8 - 12,3%; cocaethylene: C.V 5,9 - 12,3%. Detection and quantification limit values: cocaine and cocaethylene:10 ng/mL and 15 ng/mL, respectivalty; benzoylecgonine:15 ng/mL and 20 ng/mL, respectivaley. Recovery values: cocaine: 78,0 - 85,8%; benzoylecgonine: 74,0 - 79,8%; cocaethylene: 83,0 - 91,5%. The method described is advantageous compared to others, as it simultaneously detects the major analytes found in urine samples due to cocaine use and has been successfully validated |
Disciplinas: | Medicina |
Palabras clave: | Toxicología, Diagnóstico, Análisis clínicos, Validación analítica, Orina, Cromatografía de gases, Espectrometría de masas, Cocaína, Benzoilecgonina |
Keyword: | Toxicology, Diagnosis, Clinical analysis, Analytical validation, Urine, Gas chromatography, Mass spectrometry, Cocaine, Benzoylecognine |
Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |