Oral administration of eucalyptol reduces cell migration and pain-like behavior in zymosan-induced arthritis mice
Título del documento: Oral administration of eucalyptol reduces cell migration and pain-like behavior in zymosan-induced arthritis mice
Revue: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451831
ISSN: 1984-8250
Autores: 1
2
Instituciones: 1Universidade Federal do Ceara, Faculdade de Medicina, Fortaleza, Ceara. Brasil
2Universidade Federal do Ceara, Departamento de Medicina Interna, Fortaleza, Ceara. Brasil
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Rheumatoid arthritis (RA) is an inflammatory disease that utilizes nonbiologic and biologic drugs for appropriate disease management. However, high cost, adverse effects, reduced effectiveness, and risk of infection have stimulated the search for safer and more efficacious therapeutic strategies. In the present study, we aimed to evaluate the anti-inflammatory and analgesic properties of eucalyptol in an experimental model of arthritis. Mice were administered zymosan or saline intra-articularly. One hour before the zymosan administration, the mice were treated with oral eucalyptol (200-400 mg/kg) and vehicle. Cell influx, neutrophils, lymphocytes, and monocytes were measured in joint exudates. Joint pain was assessed using paw-pressure tests. Orally administered eucalyptol (200 and 400 mg/kg) significantly reduced cell influx, as well as neutrophils, lymphocytes, and monocytes, when compared with the control. Eucalyptol at a dose of 400 mg/kg significantly reversed joint pain and demonstrated analgesic activity (60%); however, 200 mg/kg failed to alter joint pain. These results indicate that oral eucalyptol promotes anti-inflammatory and analgesic activity in mice subjected to zymosan-induced arthritis
Disciplinas: Medicina
Palabras clave: Reumatología,
Farmacología,
Medicina experimental,
Eucaliptol,
Zimosan,
Artritis,
Actividad analgésica,
Actividad antiinflamatoria,
Ratones
Keyword: Rheumatology,
Pharmacology,
Experimental medicine,
Eucalyptol,
Zymosan,
Anti-inflammatory activity,
Analgesic activity,
Arthritis,
Mice
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