Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451831 |
ISSN: | 1984-8250 |
Autores: | Costa, Deiziane Viana da Silva1 Nunes, Rodolfo de Melo2 |
Instituciones: | 1Universidade Federal do Ceara, Faculdade de Medicina, Fortaleza, Ceara. Brasil 2Universidade Federal do Ceara, Departamento de Medicina Interna, Fortaleza, Ceara. Brasil |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Rheumatoid arthritis (RA) is an inflammatory disease that utilizes nonbiologic and biologic drugs for appropriate disease management. However, high cost, adverse effects, reduced effectiveness, and risk of infection have stimulated the search for safer and more efficacious therapeutic strategies. In the present study, we aimed to evaluate the anti-inflammatory and analgesic properties of eucalyptol in an experimental model of arthritis. Mice were administered zymosan or saline intra-articularly. One hour before the zymosan administration, the mice were treated with oral eucalyptol (200-400 mg/kg) and vehicle. Cell influx, neutrophils, lymphocytes, and monocytes were measured in joint exudates. Joint pain was assessed using paw-pressure tests. Orally administered eucalyptol (200 and 400 mg/kg) significantly reduced cell influx, as well as neutrophils, lymphocytes, and monocytes, when compared with the control. Eucalyptol at a dose of 400 mg/kg significantly reversed joint pain and demonstrated analgesic activity (60%); however, 200 mg/kg failed to alter joint pain. These results indicate that oral eucalyptol promotes anti-inflammatory and analgesic activity in mice subjected to zymosan-induced arthritis |
Disciplinas: | Medicina |
Palabras clave: | Reumatología, Farmacología, Medicina experimental, Eucaliptol, Zimosan, Artritis, Actividad analgésica, Actividad antiinflamatoria, Ratones |
Keyword: | Rheumatology, Pharmacology, Experimental medicine, Eucalyptol, Zymosan, Anti-inflammatory activity, Analgesic activity, Arthritis, Mice |
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