Oral administration of eucalyptol reduces cell migration and pain-like behavior in zymosan-induced arthritis mice
Document title: Oral administration of eucalyptol reduces cell migration and pain-like behavior in zymosan-induced arthritis mice
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451831
ISSN: 1984-8250
Authors: 1
2
Institutions: 1Universidade Federal do Ceara, Faculdade de Medicina, Fortaleza, Ceara. Brasil
2Universidade Federal do Ceara, Departamento de Medicina Interna, Fortaleza, Ceara. Brasil
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Rheumatoid arthritis (RA) is an inflammatory disease that utilizes nonbiologic and biologic drugs for appropriate disease management. However, high cost, adverse effects, reduced effectiveness, and risk of infection have stimulated the search for safer and more efficacious therapeutic strategies. In the present study, we aimed to evaluate the anti-inflammatory and analgesic properties of eucalyptol in an experimental model of arthritis. Mice were administered zymosan or saline intra-articularly. One hour before the zymosan administration, the mice were treated with oral eucalyptol (200-400 mg/kg) and vehicle. Cell influx, neutrophils, lymphocytes, and monocytes were measured in joint exudates. Joint pain was assessed using paw-pressure tests. Orally administered eucalyptol (200 and 400 mg/kg) significantly reduced cell influx, as well as neutrophils, lymphocytes, and monocytes, when compared with the control. Eucalyptol at a dose of 400 mg/kg significantly reversed joint pain and demonstrated analgesic activity (60%); however, 200 mg/kg failed to alter joint pain. These results indicate that oral eucalyptol promotes anti-inflammatory and analgesic activity in mice subjected to zymosan-induced arthritis
Disciplines: Medicina
Keyword: Reumatología,
Farmacología,
Medicina experimental,
Eucaliptol,
Zimosan,
Artritis,
Actividad analgésica,
Actividad antiinflamatoria,
Ratones
Keyword: Rheumatology,
Pharmacology,
Experimental medicine,
Eucalyptol,
Zymosan,
Anti-inflammatory activity,
Analgesic activity,
Arthritis,
Mice
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