An in vivo method for estimating the concentration of crotamine in a solution



Document title: An in vivo method for estimating the concentration of crotamine in a solution
Journal: The journal of venomous animals and toxins
Database: PERIÓDICA
System number: 000298586
ISSN: 0104-7930
Authors: 1
Institutions: 1Universidade Federal do Rio Grande do Sul, Instituto de Biociencias, Porto Alegre, Rio Grande do Sul. Brasil
Year:
Volumen: 3
Number: 1
Pages: 33-36
Country: Brasil
Language: Inglés
Document type: Nota breve o noticia
Approach: Experimental
English abstract very sensitive method for estimating the concentration of crotamine in a solution was developed. This method was based on the time required for the appearance of permanent hyperextension of the rear legs of mice as a function of the dose administered. This method can be used to determine toxin doses as low as 0.32 mg/kg. Its high specificity for crotamine means that it can be used to measure toxin concentrations in the presence of other proteins and polypeptides
Disciplines: Biología
Keyword: Bioquímica,
Reptiles,
Veneno de víbora,
Crotamina,
Concentración,
Métodos analíticos,
Crotalus durissus terrificus
Keyword: Biology,
Biochemistry,
Reptiles,
Snake venom,
Crotamine,
Concentration,
Analytical methods,
Crotalus durissus terrificus
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