18f-Fluorodeoxyglucose Positron Emission Tomography Versus Bone Marrow Biopsy for the Evaluation of Bone Marrow Infiltration in Newly Diagnosed Lymphoma Patients
Document title: 18f-Fluorodeoxyglucose Positron Emission Tomography Versus Bone Marrow Biopsy for the Evaluation of Bone Marrow Infiltration in Newly Diagnosed Lymphoma Patients
Journal: Revista de investigación clínica
Database: PERIÓDICA
System number: 000453172
ISSN: 0034-8376
Authors: 1
2
3
4
4
1
3
5
Institutions: 1Instituto Nacional de Cancerología, Departamento de Hematología, Ciudad de México. México
2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, División de Medicina, Ciudad de México. México
3Instituto Nacional de Cancerología, Departamento de Medicina Nuclear, Ciudad de México. México
4Instituto Nacional de Cancerología, Departamento de Hematopatologia, Ciudad de México. México
5Instituto Nacional de Cancerología, División de Investigación, Ciudad de México. México
Year:
Season: Mar-Abr
Volumen: 73
Number: 2
Pages: 79-86
Country: México
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Bone marrow evaluation (BME) is crucial for establishing an accurate staging and prognosis in lymphoma patients. Objective: The objective of the study was to study the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) against bone marrow biopsy (BMB) for BME. Methods: Five hundred patient files of newly diagnosed lymphoma patients treated at an academic medical center were reviewed for BME at diagnosis by BMB and FDG PET-CT. Diagnostic performance of FDG PET-CT for detecting bone marrow infiltration (BMI) was assessed, as well as clinical predictors for positive BMB and positive FDG PET-CT. Results: BMB was positive in 16.3% of all patients, and 28.7% had a positive FDG PET-CT for BMI. Overall, the sensitivity of FDG PET-CT was 74.1% and specificity 80.1%. As for predictors for BMB and FDG PET-CT positivity, B symptoms and thrombocytopenia were independent factors for BMI. Seventy-four patients had discordant results between BMB and FDG PET-CT, non-Hodgkin lymphoma (NHL) having the most significant discordance. This discrepancy did not affect treatment. Conclusions: FDG PET-CT shows excellent performance for the detection of BMI in Hodgkin lymphoma. For diffuse large B-cell lymphoma, we recommend performing BMB and FDG PET-CT as complementary tests. In all other NHL, a unilateral BMB is mandatory at diagnosis
Disciplines: Medicina
Keyword: Hematología,
Oncología,
Diagnóstico,
Linfoma,
Infiltración celular,
Médula ósea,
Biopsia,
Tomografía por emisión de positrones,
18F-Fluorodeoxiglucosa
Keyword: Hematology,
Oncology,
Diagnosis,
Lymphoma,
Cell infiltration,
Bone marrow,
Biopsy,
18F-Fluorodeoxyglucose,
Positron emission tomography
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