| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000453172 |
| ISSN: | 0034-8376 |
| Autores: | Aguado Vázquez, Tania M1 Olivas Martínez, Antonio2 Cancino Ramos, Uvi3 Zúüiga Tamayo, Diego A4 Lome Maldonado, María del C. A4 Rivas Vera, Silvia1 García Pérez, Francisco O3 Candelaria Hernández, Myrna G5 |
| Instituciones: | 1Instituto Nacional de Cancerología, Departamento de Hematología, Ciudad de México. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, División de Medicina, Ciudad de México. México 3Instituto Nacional de Cancerología, Departamento de Medicina Nuclear, Ciudad de México. México 4Instituto Nacional de Cancerología, Departamento de Hematopatologia, Ciudad de México. México 5Instituto Nacional de Cancerología, División de Investigación, Ciudad de México. México |
| Año: | 2021 |
| Periodo: | Mar-Abr |
| Volumen: | 73 |
| Número: | 2 |
| Paginación: | 79-86 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Bone marrow evaluation (BME) is crucial for establishing an accurate staging and prognosis in lymphoma patients. Objective: The objective of the study was to study the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) against bone marrow biopsy (BMB) for BME. Methods: Five hundred patient files of newly diagnosed lymphoma patients treated at an academic medical center were reviewed for BME at diagnosis by BMB and FDG PET-CT. Diagnostic performance of FDG PET-CT for detecting bone marrow infiltration (BMI) was assessed, as well as clinical predictors for positive BMB and positive FDG PET-CT. Results: BMB was positive in 16.3% of all patients, and 28.7% had a positive FDG PET-CT for BMI. Overall, the sensitivity of FDG PET-CT was 74.1% and specificity 80.1%. As for predictors for BMB and FDG PET-CT positivity, B symptoms and thrombocytopenia were independent factors for BMI. Seventy-four patients had discordant results between BMB and FDG PET-CT, non-Hodgkin lymphoma (NHL) having the most significant discordance. This discrepancy did not affect treatment. Conclusions: FDG PET-CT shows excellent performance for the detection of BMI in Hodgkin lymphoma. For diffuse large B-cell lymphoma, we recommend performing BMB and FDG PET-CT as complementary tests. In all other NHL, a unilateral BMB is mandatory at diagnosis |
| Disciplinas: | Medicina |
| Palabras clave: | Hematología, Oncología, Diagnóstico, Linfoma, Infiltración celular, Médula ósea, Biopsia, Tomografía por emisión de positrones, 18F-Fluorodeoxiglucosa |
| Keyword: | Hematology, Oncology, Diagnosis, Lymphoma, Cell infiltration, Bone marrow, Biopsy, 18F-Fluorodeoxyglucose, Positron emission tomography |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
