["Estresse oxidativo, les\u00f5es no genoma e processos de sinaliza\u00e7\u00e3o no controle do ciclo celular", "Oxidative stress, genome lesions and signaling pathways in cell cycle control"]
Document title: ["Estresse oxidativo, les\u00f5es no genoma e processos de sinaliza\u00e7\u00e3o no controle do ciclo celular", "Oxidative stress, genome lesions and signaling pathways in cell cycle control"]
Journal: Quimica nova
Database: PERIÓDICA
System number: 000313209
ISSN: 0100-4042
Authors: 1

2
Institutions: 1Universidade de Sao Paulo, Instituto de Ciencias Biomedicas, Sao Paulo. Brasil
2Universidade de Sao Paulo, Instituto de Quimica, Sao Paulo. Brasil
Year:
Season: Nov
Volumen: 29
Number: 6
Pages: 1340-1344
Country: Brasil
Language: Portugués
Document type: Artículo
Approach: Analítico, descriptivo
English abstract The generation of reactive oxygen species (ROS) may be both beneficial to cells, performing functions in intracellular signaling and detrimental, modifying cellular biomolecules. ROS can cause DNA damage, such as base damage and strand breaks. Organisms respond to chromosome insults by activation of a complex and hierarchical DNA-damage response pathway. The extent of DNA damages determines cell fate: cell cycle arrest and DNA repair or cell death. The ATM is a central protein in the response to DNA double-strand breaks by acting as a transducer protein. Collected evidences suggest that ATM is also involved in the response to oxidative DNA damage
Disciplines: Química,
Biología
Keyword: Bioquímica,
Biología celular,
Estrés oxidativo,
Ciclo celular,
Genoma,
Vías de señalización
Keyword: Chemistry,
Biology,
Biochemistry,
Cell biology,
Oxidative stress,
Cell cycle,
Genome,
Signaling pathways
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