Revista: | Quimica nova |
Base de datos: | PERIÓDICA |
Número de sistema: | 000313209 |
ISSN: | 0100-4042 |
Autors: | Berra, Carolina M1 Menck, Carlos F.M Mascio, Paolo Di2 |
Institucions: | 1Universidade de Sao Paulo, Instituto de Ciencias Biomedicas, Sao Paulo. Brasil 2Universidade de Sao Paulo, Instituto de Quimica, Sao Paulo. Brasil |
Any: | 2006 |
Període: | Nov |
Volum: | 29 |
Número: | 6 |
Paginació: | 1340-1344 |
País: | Brasil |
Idioma: | Portugués |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | The generation of reactive oxygen species (ROS) may be both beneficial to cells, performing functions in intracellular signaling and detrimental, modifying cellular biomolecules. ROS can cause DNA damage, such as base damage and strand breaks. Organisms respond to chromosome insults by activation of a complex and hierarchical DNA-damage response pathway. The extent of DNA damages determines cell fate: cell cycle arrest and DNA repair or cell death. The ATM is a central protein in the response to DNA double-strand breaks by acting as a transducer protein. Collected evidences suggest that ATM is also involved in the response to oxidative DNA damage |
Disciplines | Química, Biología |
Paraules clau: | Bioquímica, Biología celular, Estrés oxidativo, Ciclo celular, Genoma, Vías de señalización |
Keyword: | Chemistry, Biology, Biochemistry, Cell biology, Oxidative stress, Cell cycle, Genome, Signaling pathways |
Text complet: | Texto completo (Ver HTML) |