Estatinas hipolipêmicas e novas tendências terapêuticas



Document title: Estatinas hipolipêmicas e novas tendências terapêuticas
Journal: Quimica nova
Database: PERIÓDICA
System number: 000313423
ISSN: 0100-4042
Authors: 1
Institutions: 1Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
Year:
Season: Abr
Volumen: 30
Number: 2
Pages: 425-430
Country: Brasil
Language: Portugués
Document type: Artículo
Approach: Descriptivo, aplicado
English abstract Statins are the most used drugs for the treatment of hyperlipidemia in primary and secondary prevention, with the aim of decreasing the levels of plasmatic cholesterol- lipoproteins. Owing to their structural similarity to the substrate HMG-CoA (3-hydroxy-3-methylglutaryl-CoA), they inhibit the HMG-CoA reductase enzyme, disrupting the cholesterol biosynthesis. Currently, six therapeutic statins are available: lovastatin (Mevacor) and pravastatin (Pravachol), which are natural, sinvastatin (Zocor), a semi-synthetic derivative, and the totally synthetic statins, fluvastatin (Lescol), atorvastatin (Lipitor) and rosuvastatin (Crestor). Recent investigations have showed other important effects of statins, such as antineoplastic action and improvement in endothelial function
Disciplines: Química,
Medicina
Keyword: Química farmacéutica,
Metabolismo y nutrición,
Terapéutica,
Colesterol,
Estatinas
Keyword: Chemistry,
Medicine,
Medicinal chemistry,
Metabolism and nutrition,
Therapeutics,
Cholesterol,
Statins
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