Journal: | Quimica nova |
Database: | PERIÓDICA |
System number: | 000313423 |
ISSN: | 0100-4042 |
Authors: | Campo, Vanessa Leiria1 Carvalho, Ivone |
Institutions: | 1Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil |
Year: | 2007 |
Season: | Abr |
Volumen: | 30 |
Number: | 2 |
Pages: | 425-430 |
Country: | Brasil |
Language: | Portugués |
Document type: | Artículo |
Approach: | Descriptivo, aplicado |
English abstract | Statins are the most used drugs for the treatment of hyperlipidemia in primary and secondary prevention, with the aim of decreasing the levels of plasmatic cholesterol- lipoproteins. Owing to their structural similarity to the substrate HMG-CoA (3-hydroxy-3-methylglutaryl-CoA), they inhibit the HMG-CoA reductase enzyme, disrupting the cholesterol biosynthesis. Currently, six therapeutic statins are available: lovastatin (Mevacor) and pravastatin (Pravachol), which are natural, sinvastatin (Zocor), a semi-synthetic derivative, and the totally synthetic statins, fluvastatin (Lescol), atorvastatin (Lipitor) and rosuvastatin (Crestor). Recent investigations have showed other important effects of statins, such as antineoplastic action and improvement in endothelial function |
Disciplines: | Química, Medicina |
Keyword: | Química farmacéutica, Metabolismo y nutrición, Terapéutica, Colesterol, Estatinas |
Keyword: | Chemistry, Medicine, Medicinal chemistry, Metabolism and nutrition, Therapeutics, Cholesterol, Statins |
Full text: | Texto completo (Ver HTML) |