| Revista: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313423 |
| ISSN: | 0100-4042 |
| Autores: | Campo, Vanessa Leiria1 Carvalho, Ivone |
| Instituciones: | 1Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil |
| Año: | 2007 |
| Periodo: | Abr |
| Volumen: | 30 |
| Número: | 2 |
| Paginación: | 425-430 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Descriptivo, aplicado |
| Resumen en inglés | Statins are the most used drugs for the treatment of hyperlipidemia in primary and secondary prevention, with the aim of decreasing the levels of plasmatic cholesterol- lipoproteins. Owing to their structural similarity to the substrate HMG-CoA (3-hydroxy-3-methylglutaryl-CoA), they inhibit the HMG-CoA reductase enzyme, disrupting the cholesterol biosynthesis. Currently, six therapeutic statins are available: lovastatin (Mevacor) and pravastatin (Pravachol), which are natural, sinvastatin (Zocor), a semi-synthetic derivative, and the totally synthetic statins, fluvastatin (Lescol), atorvastatin (Lipitor) and rosuvastatin (Crestor). Recent investigations have showed other important effects of statins, such as antineoplastic action and improvement in endothelial function |
| Disciplinas: | Química, Medicina |
| Palabras clave: | Química farmacéutica, Metabolismo y nutrición, Terapéutica, Colesterol, Estatinas |
| Keyword: | Chemistry, Medicine, Medicinal chemistry, Metabolism and nutrition, Therapeutics, Cholesterol, Statins |
| Texto completo: | Texto completo (Ver HTML) |
