Crystal-associated cholangiopathy in sheep grazing Brachiaria decumbens containing the saponin protodioscin



Document title: Crystal-associated cholangiopathy in sheep grazing Brachiaria decumbens containing the saponin protodioscin
Journal: Pesquisa veterinaria brasileira
Database: PERIÓDICA
System number: 000301674
ISSN: 0100-736X
Authors: 1
2
3
4
5
Institutions: 1Universidade Federal de Mato Grosso do Sul, Departamento de Patologia, Campo Grande, Mato Grosso do Sul. Brasil
2Instituto Biologico, Sao Paulo. Brasil
3Universidade Federal de Mato Grosso do Sul, Nucleo de Ciencias Veterinarias, Campo Grande, Mato Grosso do Sul. Brasil
4Universidade Federal de Campina Grande, Hospital Veterinario, Jatoba, Paraiba. Brasil
5Universidade Federal de Goias, Escola de Veterinaria, Goiania, Goias. Brasil
Year:
Season: Ene
Volumen: 27
Number: 1
Pages: 39-42
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, descriptivo
English abstract An outbreak of hepatogenous photosensitization is reported in a flock of 28 sheep grazing Brachiaria decumbens in Mato Grosso do Sul State, Central-Western Brazil. Seven lambs and an adult sheep were affected and 6 of them died. Two surviving affected lambs and one lamb without clinical signs had increased serum values of gamma glutamyltransferase, bilirubin, and cholesterol. In two adult unaffected sheep those parameters were within normal values. An adult sheep submitted to necropsy presented moderate body condition, unilateral corneal opacity, drying of the muzzle, moderate jaundice, increased lobular pattern of the liver, and a distended gallbladder. Histological lesions were epithelial degeneration, necrosis, and hyperplasia of small bile ducts. Mild amounts of foamy macrophages were observed, mainly in the centroacinar zone. Diffuse swelling and vacuolation were observed in hepatocytes. Crystal negative images were found within bile ducts, foamy macrophages, and the lumen of some renal tubules. The heart showed multifocal areas of degeneration and necrosis of the muscle fibers. Pasture samples (Brachiaria decumbens) contained 2.36% of protodioscin. No Pithomyces chartarum spores were found in the pasture. Samples from a similar neighboring B. decumbens pasture grazed by cattle without photosensitization contained 1.63% of protodioscin isomers. Outbreaks of photosensitization caused by Brachiaria spp. are common in cattle in the Brazilian Cerrado (savanna) with about 51 million hectares of Brachiaria spp pastures. Sheep farmin
Disciplines: Medicina veterinaria y zootecnia,
Biología
Keyword: Nutrición animal,
Ovinos y caprinos,
Botánica,
Hígado,
Cristales moleculares,
Ovejas,
Protodioscina,
Saponinas,
Brachiaria decumbens,
Fotosensibilización,
Histología,
Gramíneas
Keyword: Veterinary medicine and animal husbandry,
Biology,
Animal nutrition,
Sheep and goats,
Botany,
Gramineae,
Brachiaria decumbens,
Sheep,
Liver,
Molecular crystals,
Protodioscin,
Saponins,
Photosensitization,
Histology
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