Crystal-associated cholangiopathy in sheep grazing Brachiaria decumbens containing the saponin protodioscin



Título del documento: Crystal-associated cholangiopathy in sheep grazing Brachiaria decumbens containing the saponin protodioscin
Revista: Pesquisa veterinaria brasileira
Base de datos: PERIÓDICA
Número de sistema: 000301674
ISSN: 0100-736X
Autores: 1
2
3
4
5
Instituciones: 1Universidade Federal de Mato Grosso do Sul, Departamento de Patologia, Campo Grande, Mato Grosso do Sul. Brasil
2Instituto Biologico, Sao Paulo. Brasil
3Universidade Federal de Mato Grosso do Sul, Nucleo de Ciencias Veterinarias, Campo Grande, Mato Grosso do Sul. Brasil
4Universidade Federal de Campina Grande, Hospital Veterinario, Jatoba, Paraiba. Brasil
5Universidade Federal de Goias, Escola de Veterinaria, Goiania, Goias. Brasil
Año:
Periodo: Ene
Volumen: 27
Número: 1
Paginación: 39-42
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, descriptivo
Resumen en inglés An outbreak of hepatogenous photosensitization is reported in a flock of 28 sheep grazing Brachiaria decumbens in Mato Grosso do Sul State, Central-Western Brazil. Seven lambs and an adult sheep were affected and 6 of them died. Two surviving affected lambs and one lamb without clinical signs had increased serum values of gamma glutamyltransferase, bilirubin, and cholesterol. In two adult unaffected sheep those parameters were within normal values. An adult sheep submitted to necropsy presented moderate body condition, unilateral corneal opacity, drying of the muzzle, moderate jaundice, increased lobular pattern of the liver, and a distended gallbladder. Histological lesions were epithelial degeneration, necrosis, and hyperplasia of small bile ducts. Mild amounts of foamy macrophages were observed, mainly in the centroacinar zone. Diffuse swelling and vacuolation were observed in hepatocytes. Crystal negative images were found within bile ducts, foamy macrophages, and the lumen of some renal tubules. The heart showed multifocal areas of degeneration and necrosis of the muscle fibers. Pasture samples (Brachiaria decumbens) contained 2.36% of protodioscin. No Pithomyces chartarum spores were found in the pasture. Samples from a similar neighboring B. decumbens pasture grazed by cattle without photosensitization contained 1.63% of protodioscin isomers. Outbreaks of photosensitization caused by Brachiaria spp. are common in cattle in the Brazilian Cerrado (savanna) with about 51 million hectares of Brachiaria spp pastures. Sheep farmin
Disciplinas: Medicina veterinaria y zootecnia,
Biología
Palabras clave: Nutrición animal,
Ovinos y caprinos,
Botánica,
Hígado,
Cristales moleculares,
Ovejas,
Protodioscina,
Saponinas,
Brachiaria decumbens,
Fotosensibilización,
Histología,
Gramíneas
Keyword: Veterinary medicine and animal husbandry,
Biology,
Animal nutrition,
Sheep and goats,
Botany,
Gramineae,
Brachiaria decumbens,
Sheep,
Liver,
Molecular crystals,
Protodioscin,
Saponins,
Photosensitization,
Histology
Texto completo: Texto completo (Ver HTML)