Revista: | Memorias do Instituto Oswaldo Cruz |
Base de datos: | PERIÓDICA |
Número de sistema: | 000459479 |
ISSN: | 0074-0276 |
Autores: | Mázala de Oliveira, Thalita1 Jannini de Sá, Yago Amigo Pinho2 Carvalho, Vinicius de Frias1 |
Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Cedars-Sinai Medical Center, Medicine Department, Los Angeles, California. Estados Unidos de América |
Año: | 2023 |
Volumen: | 118 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | Diabetes is a chronic metabolic disease caused by a reduction in the production and/or action of insulin, with consequent development of hyperglycemia. Diabetic patients, especially those who develop neuropathy, presented dysbiosis, with an increase in the proportion of pathogenic bacteria and a decrease in the butyrate-producing bacteria. Due to this dysbiosis, diabetic patients presented a weakness of the intestinal permeability barrier and high bacterial product translocation to the bloodstream, in parallel to a high circulating levels of pro-inflammatory cytokines such as TNF-α. In this context, we propose here that dysbiosis-induced increased systemic levels of bacterial products, like lipopolysaccharide (LPS), leads to an increase in the production of pro-inflammatory cytokines, including TNF-α, by Schwann cells and spinal cord of diabetics, being crucial for the development of neuropathy |
Disciplinas: | Medicina |
Palabras clave: | Endocrinología, Neurología, Diabetes, Disbiosis, Microbiota intestinal, Inflamación, Neuropatías |
Keyword: | Endocrinology, Neurology, Diabetes, Dysbiosis, Intestinal microbiota, Inflammation, Neuropathies |
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