| Revue: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459479 |
| ISSN: | 0074-0276 |
| Autores: | Mázala de Oliveira, Thalita1 Jannini de Sá, Yago Amigo Pinho2 Carvalho, Vinicius de Frias1 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Cedars-Sinai Medical Center, Medicine Department, Los Angeles, California. Estados Unidos de América |
| Año: | 2023 |
| Volumen: | 118 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Diabetes is a chronic metabolic disease caused by a reduction in the production and/or action of insulin, with consequent development of hyperglycemia. Diabetic patients, especially those who develop neuropathy, presented dysbiosis, with an increase in the proportion of pathogenic bacteria and a decrease in the butyrate-producing bacteria. Due to this dysbiosis, diabetic patients presented a weakness of the intestinal permeability barrier and high bacterial product translocation to the bloodstream, in parallel to a high circulating levels of pro-inflammatory cytokines such as TNF-α. In this context, we propose here that dysbiosis-induced increased systemic levels of bacterial products, like lipopolysaccharide (LPS), leads to an increase in the production of pro-inflammatory cytokines, including TNF-α, by Schwann cells and spinal cord of diabetics, being crucial for the development of neuropathy |
| Disciplinas: | Medicina |
| Palabras clave: | Endocrinología, Neurología, Diabetes, Disbiosis, Microbiota intestinal, Inflamación, Neuropatías |
| Keyword: | Endocrinology, Neurology, Diabetes, Dysbiosis, Intestinal microbiota, Inflammation, Neuropathies |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
