| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000452433 |
| ISSN: | 0074-0276 |
| Authors: | Pinto, Marcelo Alves1 Silva, Alexandre dos Santos da1 Rodrigues, Daniela Del Rosario Flores1 Müller, Rodrigo2 Vasconcelos, Gentil Arthur Lins Bentes Mendonça de1 Neves, Patrícia Cristina da Costa2 Oliveira, Jaqueline Mendes de1 Marchevsky, Renato Sergio2 |
| Institutions: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Fundacao Oswaldo Cruz, Instituto de Tecnologia em Imunobiologicos, Rio de Janeiro. Brasil |
| Year: | 2022 |
| Volumen: | 117 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Laboratory animals are essential mainly for experiments aiming to study pathogenesis and evaluate antivirals and vaccines against emerging human infectious diseases. Preclinical studies of coronavirus disease 19 (COVID-19) pathogenesis have used several animal species as models: transgenic human ACE2 mice (K18 mice), inbred BALB/c or C57BL/6N mice, ferrets, minks, domestic cats and dogs, hamsters, and macaques. However, the choice of an animal model relies on several limitations. Besides the host susceptibility, the researcher’s experience with animal model management and the correct interpretation of clinical and laboratory records are crucial to succeed in preclinical translational research. Here, we summarise pathological and clinical findings correlated with virological data and immunological changes observed from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experimental infections using different well-established SARS-CoV-2 animal model species. This essay aims to critically evaluate the current state of animal model translation to clinical data, as described in the human SARS-CoV-2 infection |
| Disciplines: | Medicina |
| Keyword: | Virus, Medicina experimental, SARS-CoV-2, Modelos animales, Lesión neurológica, Lesión pulmonar, Patología experimental |
| Keyword: | Virus, Experimental medicine, SARS-CoV-2, Animal models, Neurological lesions, Lung injury, Experimental pathology |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
