| Journal: | Journal of the Brazilian Chemical Society |
| Database: | PERIÓDICA |
| System number: | 000310732 |
| ISSN: | 0103-5053 |
| Authors: | Booth, Susan E1 Jenkins, Paul R Swain, Christopher J2 |
| Institutions: | 1Leicester University, Department of Chemistry, Leicester, Leicestershire. Reino Unido 2Merck, Sharp and Dohme, Harlow, Essex. Reino Unido |
| Year: | 1998 |
| Season: | Ago |
| Volumen: | 9 |
| Number: | 4 |
| Pages: | 389-395 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Chiral oxime ether 2 and Oxime ester 4 have been prepared by alkylation and esterification of the oxime 1. Racemic hydroxylamine 6 and chiral hydroxylamine 10 have been synthesised from N-hydroxysuccinimide and the corresponding alcohol in the presence of diethylazodicarboxylate, the two products were converted into the oxime ethers 7 and 11 respectively. The intramolecular radical cyclisation reactions of these oxime ethers and esters has been studied, successful reaction was observed to produce alkyl hydroxylamines 3, 8 and 12 |
| Portuguese abstract | O éter-oxima quiral 2 e o éster-oxima 4 foram preparados para alquilação e esterificação da oxina 1. Hidroxiamina racêmica 6 e a hidroxiamina 10 foram sintetisadas a partir de N-hidroxipucanimida e o álcool correspondente na presença de di etil azodicarboxilato, e os dois produtos convertidos nos éteres-oximas 7 e 11 respectivamente. As reações de ciclização radicalar intramoleculares desses éteres e ésteres-oxima foram estudadas; a formação das alquil hidróxi-aminas 3, 8 e 12 foi observada nas reações bem sucedidas |
| Disciplines: | Química |
| Keyword: | Química orgánica, Hidroxilaminas racémicas, Ester de oxima, Reacciones intramoleculares, Ciclización radical, Moléculas quirales, Eter de oxima |
| Keyword: | Chemistry, Organic chemistry, Racemic hydroxylamines, Oxime ester, Intramolecular reactions, Radical cyclization, Chiral molecules, Oxime ether |
| Full text: | Texto completo (Ver HTML) |
