Small cell bladder cancer: should we consider prophylactic cranial irradiation?
Document title: Small cell bladder cancer: should we consider prophylactic cranial irradiation?
Journal: International braz j urol
Database: PERIÓDICA
System number: 000434817
ISSN: 1677-5538
Authors: 1
1
1
1
1
1
1
1
1
Institutions: 1University of Pittsburgh, School of Medicine, Pittsburgh, Pensilvania. Estados Unidos de América
Year:
Season: Mar-Abr
Volumen: 45
Number: 2
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Purpose: To describe the clinical characteristics, treatment patterns, and outcomes in patients with small cell bladder cancer at our institution, including those who received prophylactic cranial irradiation (PCI) for the prevention of intracranial recurrence. Materials and Methods: Patients with small cell bladder cancer treated at a single institution between January 1990 and August 2015 were identified and analyzed retrospectively for demographics, tumor stage, treatment, and overall survival. Results: Of 44 patients diagnosed with small cell bladder cancer, 11 (25%) had metastatic disease at the time of presentation. Treatment included systemic chemotherapy (70%), radical surgery (59%), and local radiation (39%). Six patients (14%) received PCI. Median overall survival was 10 months (IQR 4 – 41). Patients with extensive disease had worse overall survival than those with organ confined disease (8 months vs. 36 months, respectively, p = 0.04). Among those who received PCI, 33% achieved 5 - year survival. Conclusion: Outcomes for patients with small cell bladder cancer remain poor. Further research is indicated to determine if PCI increases overall survival in small call bladder cancer patients, especially those with extensive disease who respond to chemotherapy
Disciplines: Medicina
Keyword: Urología,
Oncología,
Cirugía,
Carcinoma de células pequeñas,
Vejiga urinaria,
Metástasis,
Profilaxis,
Irradiación craneal
Keyword: Urology,
Oncology,
Surgery,
Small cells carcinoma,
Urinary bladder,
Metastasis,
Prophylaxis,
Cranial irradiation
Full text: Texto completo (Ver HTML) Texto completo (Ver PDF)