Revista: | International braz j urol |
Base de datos: | PERIÓDICA |
Número de sistema: | 000434817 |
ISSN: | 1677-5538 |
Autores: | Morgan, Tara Nikonow1 Turner II, Robert M1 Baptiste, Julian1 Lyon, Timothy D1 Maranchie, Jodi K1 Hrebinko, Ronald L1 Davies, Benjamin J1 Gingrich, Jeffrey R1 Jacobs, Bruce L1 |
Instituciones: | 1University of Pittsburgh, School of Medicine, Pittsburgh, Pensilvania. Estados Unidos de América |
Año: | 2019 |
Periodo: | Mar-Abr |
Volumen: | 45 |
Número: | 2 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | Purpose: To describe the clinical characteristics, treatment patterns, and outcomes in patients with small cell bladder cancer at our institution, including those who received prophylactic cranial irradiation (PCI) for the prevention of intracranial recurrence. Materials and Methods: Patients with small cell bladder cancer treated at a single institution between January 1990 and August 2015 were identified and analyzed retrospectively for demographics, tumor stage, treatment, and overall survival. Results: Of 44 patients diagnosed with small cell bladder cancer, 11 (25%) had metastatic disease at the time of presentation. Treatment included systemic chemotherapy (70%), radical surgery (59%), and local radiation (39%). Six patients (14%) received PCI. Median overall survival was 10 months (IQR 4 – 41). Patients with extensive disease had worse overall survival than those with organ confined disease (8 months vs. 36 months, respectively, p = 0.04). Among those who received PCI, 33% achieved 5 - year survival. Conclusion: Outcomes for patients with small cell bladder cancer remain poor. Further research is indicated to determine if PCI increases overall survival in small call bladder cancer patients, especially those with extensive disease who respond to chemotherapy |
Disciplinas: | Medicina |
Palabras clave: | Urología, Oncología, Cirugía, Carcinoma de células pequeñas, Vejiga urinaria, Metástasis, Profilaxis, Irradiación craneal |
Keyword: | Urology, Oncology, Surgery, Small cells carcinoma, Urinary bladder, Metastasis, Prophylaxis, Cranial irradiation |
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