| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459241 |
| ISSN: | 1415-4757 |
| Autores: | Diniz, Isabela Guerreiro1 Noce, Rosilene Reis Della2 Pereira, Ana Paula2 Silva, Aylla Núbia Lima Martins da1 Sacuena, Eliene Rodrigues Putira1 Lemes, Renan Barbosa3 Cardoso Costa, Greice de Lemos1 Araújo, Gilderlânio Santana1 Machado, Jéssica Lígia Picanço1 Figueiredo, Fernanda Andreza de Pinho Lott1 Hümemeier, Tábita3 Guerreiro, João Farias1 |
| Instituciones: | 1Universidade Federal do Para, Instituto de Ciencias Biologicas, Belem, Para. Brasil 2Universidade Federal do Para, Instituto de Ciencias da Saude, Belem, Para. Brasil 3Universidade de Sao Paulo, Departamento de Genetica e Biologia Evolutiva, Sao Paulo. Brasil |
| Año: | 2022 |
| Volumen: | 45 |
| Número: | 2 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Genética, Metabolismo y nutrición, Diabetes, Indígenas, Amazonas, Brasil, SNP |
| Keyword: | Genetics, Metabolism and nutrition, Diabetes, Indigenous, Amazon, Brazil, SNP |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
