Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon



Título del documento: Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon
Revista: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000459241
ISSN: 1415-4757
Autores: 1
2
2
1
1
3
1
1
1
1
3
1
Instituciones: 1Universidade Federal do Para, Instituto de Ciencias Biologicas, Belem, Para. Brasil
2Universidade Federal do Para, Instituto de Ciencias da Saude, Belem, Para. Brasil
3Universidade de Sao Paulo, Departamento de Genetica e Biologia Evolutiva, Sao Paulo. Brasil
Año:
Volumen: 45
Número: 2
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants
Disciplinas: Biología,
Medicina
Palabras clave: Genética,
Metabolismo y nutrición,
Diabetes,
Indígenas,
Amazonas,
Brasil,
SNP
Keyword: Genetics,
Metabolism and nutrition,
Diabetes,
Indigenous,
Amazon,
Brazil,
SNP
Texto completo: Texto completo (Ver HTML) Texto completo (Ver PDF)