| Journal: | Electronic journal of biotechnology |
| Database: | PERIÓDICA |
| System number: | 000359295 |
| ISSN: | 0717-3458 |
| Authors: | Vilos, Cristian1 Constandil, Luis1 Herrera, Natalia2 Solar, Paula2 Escobar Fica, Jorge3 Velásquez, Luis Alberto1 |
| Institutions: | 1Universidad de Santiago de Chile, Facultad de Química y Biología, Santiago de Chile. Chile 2Universidad Andrés Bello, Facultad de Medicina, Santiago de Chile. Chile 3Pontificia Universidad Católica de Valparaíso, Facultad de Ciencias, Curauma, Valparaíso. Chile |
| Year: | 2012 |
| Volumen: | 15 |
| Number: | 4 |
| Country: | Chile |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The infectious diseases in the livestock breeding industry represent a significant drawback that generates substantial economic loss and have led to the indiscriminate use of antibiotics. The formulation of polymeric microparticles loaded with antibiotics for veterinary use can: reduce the number of required doses; protect the drug from inactivation; and maintain a sustained-release of the antibiotic drug at effective levels. Accomplishing all of these goals would have a significant economic and animal health impact on the livestock breeding industry. Results: In this work, we formulated ceftiofur-loaded PHBV microparticles (PHBV-CEF) with a spherical shape, a smooth surface and diameter sizes between 1.65 and 2.37 μm. The encapsulation efficiency was 39.5 ± 1.1% w/w, and we obtained a sustained release of ceftiofur in PBS-buffer (pH 7.4) over 7 days. The antibacterial activity of ceftiofur was preserved after the encapsulation procedure, and toxicity of PHBV-CEF microparticles evaluated by MTS was represented by an IC50 > 10 mg/mL. Conclusions: Our results suggest that PHBV-CEF particles have a potential application for improving the treatment of infectious diseases in the livestock breeding industry |
| Disciplines: | Medicina veterinaria y zootecnia, Química |
| Keyword: | Medicina veterinaria, Química farmacéutica, Biotecnología, Ganado, Liberación de fármacos, Micropartículas poliméricas, Ceftiofur |
| Keyword: | Veterinary medicine and animal husbandry, Chemistry, Veterinary medicine, Medicinal chemistry, Biotechnology, Livestock, Drug delivery, Polymeric microparticles, Ceftiofur |
| Full text: | Texto completo (Ver HTML) |
