| Journal: | Brazilian journal of chemical engineering |
| Database: | PERIÓDICA |
| System number: | 000308804 |
| ISSN: | 0104-6632 |
| Authors: | Sousa, M.F.V.Q1 Lopes, C.E Pereira-Junior, N2 |
| Institutions: | 1Universidade Federal de Pernambuco, Departamento de Antibioticos, Recife, Pernambuco. Brasil 2Universidade Federal do Rio de Janeiro, Departamento de Engenharia Bioquimica, Rio de Janeiro. Brasil |
| Year: | 2002 |
| Season: | Jul |
| Volumen: | 19 |
| Number: | 3 |
| Pages: | 277-285 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | S. parvulus was selected from three species of that produce actinomycins, as it has the greatest antibiotic activity (152 mg/L) and produces only actinomycin-D. Aiming at improving the antibiotic production in shaken flasks, the substitution of glucose by fructose in concentrations of 20, 30 and 40 g/L was investigated. In all cases this replacement led to an increase in the antibiotic production, reaching a maximum concentration of 635 mg/L for an initial fructose concentration of 30 g/L. In experiments conducted in a bioreactor at different degrees of aeration (0.5, 1.0 and 1.5 vvm) and stirring speeds (300 and 500 rpm), it was found that the greatest antibiotic production (1530 mg/L) occurred with a aeration of 1.5 vvm and a stirring speed of 500 rpm. The fermented medium showed the rheological behavior of a pseudoplastic fluid |
| Disciplines: | Química |
| Keyword: | Fermentaciones, Química farmacéutica, Reología, Streptomyces parvulus, Streptomyces felleus, Streptomyces regensis, Antibióticos, Bioproducción, Actinomicina D |
| Keyword: | Chemistry, Fermentation, Medicinal chemistry, Rheology, Streptomyces parvulus, Streptomyces felleus, Streptomyces regensis, Antibiotics, Bioproduction, Actinomycin D |
| Full text: | Texto completo (Ver HTML) |
