Revista: | Brazilian journal of chemical engineering |
Base de datos: | PERIÓDICA |
Número de sistema: | 000308804 |
ISSN: | 0104-6632 |
Autores: | Sousa, M.F.V.Q1 Lopes, C.E Pereira-Junior, N2 |
Instituciones: | 1Universidade Federal de Pernambuco, Departamento de Antibioticos, Recife, Pernambuco. Brasil 2Universidade Federal do Rio de Janeiro, Departamento de Engenharia Bioquimica, Rio de Janeiro. Brasil |
Año: | 2002 |
Periodo: | Jul |
Volumen: | 19 |
Número: | 3 |
Paginación: | 277-285 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | S. parvulus was selected from three species of that produce actinomycins, as it has the greatest antibiotic activity (152 mg/L) and produces only actinomycin-D. Aiming at improving the antibiotic production in shaken flasks, the substitution of glucose by fructose in concentrations of 20, 30 and 40 g/L was investigated. In all cases this replacement led to an increase in the antibiotic production, reaching a maximum concentration of 635 mg/L for an initial fructose concentration of 30 g/L. In experiments conducted in a bioreactor at different degrees of aeration (0.5, 1.0 and 1.5 vvm) and stirring speeds (300 and 500 rpm), it was found that the greatest antibiotic production (1530 mg/L) occurred with a aeration of 1.5 vvm and a stirring speed of 500 rpm. The fermented medium showed the rheological behavior of a pseudoplastic fluid |
Disciplinas: | Química |
Palabras clave: | Fermentaciones, Química farmacéutica, Reología, Streptomyces parvulus, Streptomyces felleus, Streptomyces regensis, Antibióticos, Bioproducción, Actinomicina D |
Keyword: | Chemistry, Fermentation, Medicinal chemistry, Rheology, Streptomyces parvulus, Streptomyces felleus, Streptomyces regensis, Antibiotics, Bioproduction, Actinomycin D |
Texto completo: | Texto completo (Ver HTML) |