| Journal: | Biological research |
| Database: | PERIÓDICA |
| System number: | 000269180 |
| ISSN: | 0716-9760 |
| Authors: | Pérez, José M1 Pradenas, Gonzalo A Navarro, Claudio A Henríquez, Daniel R Pichuantes, Sergio E2 Vásquez, Claudia C |
| Institutions: | 1Universidad de Santiago de Chile, Facultad de Química y Biología, Santiago de Chile. Chile 2Chiron Corporation, Blood Testing Division, Emeryville, California. Estados Unidos de América |
| Year: | 2006 |
| Volumen: | 39 |
| Number: | 4 |
| Pages: | 661-668 |
| Country: | Chile |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Salmonella entérica serovar Typhimurium cells expressing the cadA gene of Geobacillus stearothermophilus LV exhibit a hypersensitive phenotype to cadmium chloride. Deletion of the ORF STM3576 from the Salmonella genome resulted in cadmium, lead and zinc sensitivity, confirming that this ORF is a homologue of the zntA gene. The observed sensitivity was reverted upon expression of the G. stearothermophilus LV cadA gene. These results indicate that the cadA gene product is involved in Cd, Pb and Zn resistance as a classical P-type ATPase and strongly suggest that the observed hypersensitive phenotype to these metals can be related to the function of the host zntA gene product |
| Disciplines: | Biología, Química |
| Keyword: | Bacterias, Genética, Bioquímica, Genes, Geobacillus stearothermophilus, Salmonella enterica, Cadmio, Plomo, Zinc, Gene ZntA |
| Keyword: | Biology, Chemistry, Bacteria, Genetics, Biochemistry, Genes, Salmonella enterica, Cadmium, Lead, Geobacillus stearothermophilus, Zinc |
| Full text: | Texto completo (Ver HTML) |
