| Journal: | Biocell |
| Database: | PERIÓDICA |
| System number: | 000330407 |
| ISSN: | 0327-9545 |
| Authors: | Zhou, Liping1 Guo, Xiaolin1 Ba, JIng1 Zhao, Lianshuang1 |
| Institutions: | 1China Medical University, First Affiliated Hospital, Shenyang. China |
| Year: | 2010 |
| Season: | Ago |
| Volumen: | 34 |
| Number: | 2 |
| Pages: | 91-94 |
| Country: | Argentina |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL- 12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration |
| Disciplines: | Biología, Medicina |
| Keyword: | Biología celular, Hematología, Leucemia mieloide aguda, Migración celular, Urópodos, Acido hialurónico |
| Keyword: | Biology, Medicine, Cell biology, Hematology, Acute myeloid leukemia, Cell migration, Uropods, Hyaluronic acid |
| Full text: | Texto completo (Ver PDF) |
