| Revue: | Biocell |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000330407 |
| ISSN: | 0327-9545 |
| Autores: | Zhou, Liping1 Guo, Xiaolin1 Ba, JIng1 Zhao, Lianshuang1 |
| Instituciones: | 1China Medical University, First Affiliated Hospital, Shenyang. China |
| Año: | 2010 |
| Periodo: | Ago |
| Volumen: | 34 |
| Número: | 2 |
| Paginación: | 91-94 |
| País: | Argentina |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL- 12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Biología celular, Hematología, Leucemia mieloide aguda, Migración celular, Urópodos, Acido hialurónico |
| Keyword: | Biology, Medicine, Cell biology, Hematology, Acute myeloid leukemia, Cell migration, Uropods, Hyaluronic acid |
| Texte intégral: | Texto completo (Ver PDF) |
