Journal: | Archives of clinical psychiatry |
Database: | PERIÓDICA |
System number: | 000429030 |
Authors: | Wysokinski, Adam1 Margulska, Aleksandra1 Kozlowska, Elz-Bieta2 Brzezinska-Blaszcsyk, Ewa2 |
Institutions: | 1Medical University of Lodz, Department of Old Age Psychiatry and Psychotic Disorders, Banacha, Lodz. Polonia 2Medical University of Lodz, Department of Experimental Immunology, Banacha, Lodz. Polonia |
Year: | 2019 |
Season: | May-Jun |
Volumen: | 46 |
Number: | 3 |
Pages: | 66-71 |
Country: | Brasil |
Language: | Inglés |
Document type: | Artículo |
Approach: | Analítico, descriptivo |
English abstract | Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is increased in patients with bipolar disorder. Objectives The aim of this study is to re-evaluate serum LL-37 levels in patients with euthymic bipolar disorder and in healthy controls, matched for anthropometric and body composition parameters. Methods 36 adult patients with euthymic bipolar disorder and 68 non-depressed adults were included into the study. Concentration of LL-37 in serum was assessed using ELISA method. Detailed anthropometric measurements, body composition and biochemical analyses were performed. Results There was a statistically significant difference (p = 0.01) in serum LL-37 level between patients with bipolar disorder (4.97 ± 7.98 ng/mL) and control subjects (1.78 ± 2.69 ng/mL). Discussion Results of this study indicate that LL-37 serum level is increased in euthymic bipolar disorder patients. We found that this increase could not be attributed to analyzed anthropometric or body composition parameters |
Disciplines: | Medicina |
Keyword: | Psiquiatría, Inmunología, Péptidos antimicrobianos, Catelicidinas, Eutimia, Trastorno bipolar |
Keyword: | Psychiatry, Immunology, Antimicrobial peptides, Cathelicidins, Euthymia, Bipolar disorder |
Full text: | Texto completo (Ver HTML) |