Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status



Título del documento: Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
Revista: Archives of clinical psychiatry
Base de datos: PERIÓDICA
Número de sistema: 000429030
Autores: 1
1
2
2
Instituciones: 1Medical University of Lodz, Department of Old Age Psychiatry and Psychotic Disorders, Banacha, Lodz. Polonia
2Medical University of Lodz, Department of Experimental Immunology, Banacha, Lodz. Polonia
Año:
Periodo: May-Jun
Volumen: 46
Número: 3
Paginación: 66-71
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is increased in patients with bipolar disorder. Objectives The aim of this study is to re-evaluate serum LL-37 levels in patients with euthymic bipolar disorder and in healthy controls, matched for anthropometric and body composition parameters. Methods 36 adult patients with euthymic bipolar disorder and 68 non-depressed adults were included into the study. Concentration of LL-37 in serum was assessed using ELISA method. Detailed anthropometric measurements, body composition and biochemical analyses were performed. Results There was a statistically significant difference (p = 0.01) in serum LL-37 level between patients with bipolar disorder (4.97 ± 7.98 ng/mL) and control subjects (1.78 ± 2.69 ng/mL). Discussion Results of this study indicate that LL-37 serum level is increased in euthymic bipolar disorder patients. We found that this increase could not be attributed to analyzed anthropometric or body composition parameters
Disciplinas: Medicina
Palabras clave: Psiquiatría,
Inmunología,
Péptidos antimicrobianos,
Catelicidinas,
Eutimia,
Trastorno bipolar
Keyword: Psychiatry,
Immunology,
Antimicrobial peptides,
Cathelicidins,
Euthymia,
Bipolar disorder
Texto completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-60832019000300066&lng=en&nrm=iso&tlng=en