| Journal: | Archives of clinical psychiatry |
| Database: | PERIÓDICA |
| System number: | 000428715 |
| Authors: | Pehlivan, Sacide1 Cetinay Aydin, Pinar2 Atilla Uysal, Mehmet3 Senturk Ciftci, Hayriye1 Kasım Yavuz, Fatih2 Aydin, Nazan2 Feyda Nursal, Ayse4 |
| Institutions: | 1Istanbul University, Istanbul Faculty of Medicine, Estambul. Turquía 2Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Department of Psychiatry, Estambul. Turquía 3Yedikule Hospital For Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Chest Diseases, Estambul. Turquía 4Hitit University, Faculty of Medicine, Corum. Turquía |
| Year: | 2019 |
| Season: | Ene-Feb |
| Volumen: | 46 |
| Number: | 1 |
| Pages: | 21-24 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Schizophrenia (Sch) is a severe and chronic mental illness. Smoking prevalence is higher in patients with Sch than general population. We aimed to investigate the effects of MAOB gene A644G variant on nicotine dependence (ND) and Sch+ND risk in Turkish population and to evaluate by bioinformatic analysis. Methods Present study included 161 individuals with ND, 223 patients with Sch+ND, and 96 non-smoker controls. MAOB A644G variant was analyzed using PCR-RFLP method. As the MAOB gene is located on the X chromosome, each gender was analysed separately. Results The total distributions of AA, AG and GG genotypes of MAOB gene A644G were 44.7%, 22.4% and 32.9% in the ND group, 45.3%, 25.1% and 29.6% in the Sch+ND group and, 44.8, 22.9% and 32.3% in non-smoker controls. No significant differences were observed between groups for the MAOB A644G genotype and allele frequencies when female group compared to male group (p > 0.05). Examination of disease associations of SNPs from each miRNA gene region in GWAS databases yielded results for aging, bipolar disorder, autoimmune, and neurological diseases. Discussion Our results indicate that the MAOB gene A644G variant is not associated with ND and/or Sch susceptibility in the Turkish population |
| Disciplines: | Medicina |
| Keyword: | Psiquiatría, Toxicología, Nicotina, Dependencia, Monoamino oxidasa B, Esquizofrenia |
| Keyword: | Psychiatry, Toxicology, Nicotine, Dependence, Monoamine oxidase B, Schizophrenia |
| Full text: | Texto completo (Ver HTML) |
