Effect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk



Título del documento: Effect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk
Revista: Archives of clinical psychiatry
Base de datos: PERIÓDICA
Número de sistema: 000428715
Autors: 1
2
3
1
2
2
4
Institucions: 1Istanbul University, Istanbul Faculty of Medicine, Estambul. Turquía
2Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Department of Psychiatry, Estambul. Turquía
3Yedikule Hospital For Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Chest Diseases, Estambul. Turquía
4Hitit University, Faculty of Medicine, Corum. Turquía
Any:
Període: Ene-Feb
Volum: 46
Número: 1
Paginació: 21-24
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Schizophrenia (Sch) is a severe and chronic mental illness. Smoking prevalence is higher in patients with Sch than general population. We aimed to investigate the effects of MAOB gene A644G variant on nicotine dependence (ND) and Sch+ND risk in Turkish population and to evaluate by bioinformatic analysis. Methods Present study included 161 individuals with ND, 223 patients with Sch+ND, and 96 non-smoker controls. MAOB A644G variant was analyzed using PCR-RFLP method. As the MAOB gene is located on the X chromosome, each gender was analysed separately. Results The total distributions of AA, AG and GG genotypes of MAOB gene A644G were 44.7%, 22.4% and 32.9% in the ND group, 45.3%, 25.1% and 29.6% in the Sch+ND group and, 44.8, 22.9% and 32.3% in non-smoker controls. No significant differences were observed between groups for the MAOB A644G genotype and allele frequencies when female group compared to male group (p > 0.05). Examination of disease associations of SNPs from each miRNA gene region in GWAS databases yielded results for aging, bipolar disorder, autoimmune, and neurological diseases. Discussion Our results indicate that the MAOB gene A644G variant is not associated with ND and/or Sch susceptibility in the Turkish population
Disciplines Medicina
Paraules clau: Psiquiatría,
Toxicología,
Nicotina,
Dependencia,
Monoamino oxidasa B,
Esquizofrenia
Keyword: Psychiatry,
Toxicology,
Nicotine,
Dependence,
Monoamine oxidase B,
Schizophrenia
Text complet: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-60832019000100021&lng=en&nrm=iso&tlng=en