Biomarkers in mood disorders research: developing new and improved therapeutics



Document title: Biomarkers in mood disorders research: developing new and improved therapeutics
Journal: Archives of clinical psychiatry
Database: PERIÓDICA
System number: 000380330
ISSN: 1806-938X
Authors: 1
1
1
1
1
1
1
1
1
1
Institutions: 1National Institutes of Health, National Institute of Mental Health, Bethesda, Maryland. Estados Unidos de América
Year:
Volumen: 41
Number: 5
Pages: 131-134
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Recently, surrogate neurobiological biomarkers that correlate with target engagement and therapeutic response have been developed and tested in early phase studies of mood disorders. Objective The identification of biomarkers could help develop personalized psychiatric treatments that may impact public health. Methods These biomarkers, which are associated with clinical response post-treatment, can be directly validated using multimodal approaches including genetic tools, proteomics/metabolomics, peripheral measures, neuroimaging, biostatistical predictors, and clinical predictors. Results To date, early phase biomarker studies have sought to identify measures that can serve as “biosignatures”, or biological patterns of clinical response. These studies have also sought to identify clinical predictors and surrogate outcomes associated with pathophysiological domains consistently described in the National Institute of Mental Health’s (NIMH) new Research Domain Criteria (RDoC). Using the N-methyl-D-aspartate (NMDA) antagonist ketamine as an example, we identified changes in several domains (clinical, cognitive, and neurophysiological) that predicted ketamine’s rapid and sustained antidepressant effects in individuals with treatment-resistant major depressive disorder (MDD) or bipolar depression. Discussion These approaches may ultimately provide clues into the neurobiology of psychiatric disorders and may have enormous impact Backon the development of novel therapeutics
Disciplines: Medicina
Keyword: Diagnóstico,
Psiquiatría,
Terapéutica y rehabilitación,
Depresión,
Trastorno bipolar,
Ansiedad,
Biomarcadores,
Desarrollo de fármacos,
Neurobiología
Keyword: Medicine,
Diagnosis,
Psychiatry,
Therapeutics and rehabilitation,
Depression,
Bipolar disorder,
Anxiety,
Biomarkers,
Drug development,
Neurobiology
Full text: Texto completo (Ver HTML)