| Revista: | Archives of clinical psychiatry |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000380330 |
| ISSN: | 1806-938X |
| Autores: | Niciu, Mark J1 Mathews, Daniel C1 Ionescu, Dawn F1 Richards, Erica M1 Furey, Maura L1 Yuan, Peixiong1 Nugent, Allison C1 Henter, Ioline D1 Machado-Vieira, Rodrigo1 Zarate-Junior, Carlos A1 |
| Instituciones: | 1National Institutes of Health, National Institute of Mental Health, Bethesda, Maryland. Estados Unidos de América |
| Año: | 2014 |
| Volumen: | 41 |
| Número: | 5 |
| Paginación: | 131-134 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Recently, surrogate neurobiological biomarkers that correlate with target engagement and therapeutic response have been developed and tested in early phase studies of mood disorders. Objective The identification of biomarkers could help develop personalized psychiatric treatments that may impact public health. Methods These biomarkers, which are associated with clinical response post-treatment, can be directly validated using multimodal approaches including genetic tools, proteomics/metabolomics, peripheral measures, neuroimaging, biostatistical predictors, and clinical predictors. Results To date, early phase biomarker studies have sought to identify measures that can serve as “biosignatures”, or biological patterns of clinical response. These studies have also sought to identify clinical predictors and surrogate outcomes associated with pathophysiological domains consistently described in the National Institute of Mental Health’s (NIMH) new Research Domain Criteria (RDoC). Using the N-methyl-D-aspartate (NMDA) antagonist ketamine as an example, we identified changes in several domains (clinical, cognitive, and neurophysiological) that predicted ketamine’s rapid and sustained antidepressant effects in individuals with treatment-resistant major depressive disorder (MDD) or bipolar depression. Discussion These approaches may ultimately provide clues into the neurobiology of psychiatric disorders and may have enormous impact Backon the development of novel therapeutics |
| Disciplinas: | Medicina |
| Palabras clave: | Diagnóstico, Psiquiatría, Terapéutica y rehabilitación, Depresión, Trastorno bipolar, Ansiedad, Biomarcadores, Desarrollo de fármacos, Neurobiología |
| Keyword: | Medicine, Diagnosis, Psychiatry, Therapeutics and rehabilitation, Depression, Bipolar disorder, Anxiety, Biomarkers, Drug development, Neurobiology |
| Texto completo: | Texto completo (Ver HTML) |
