| Journal: | ARBS. Annual review of biomedical sciences |
| Database: | PERIÓDICA |
| System number: | 000270163 |
| ISSN: | 1678-4618 |
| Authors: | Anumanthan, Govindaraj1 Pope IV, John C2 |
| Institutions: | 1Vanderbilt University, Medical Center, Nashville, Tennessee. Estados Unidos de América 2Vanderbilt Children’s Hospital, Division of Pediatric Surgery, Nashville, Tennessee. Estados Unidos de América |
| Year: | 2008 |
| Volumen: | 10 |
| Pages: | 1-5 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Revisión bibliográfica |
| Approach: | Analítico |
| English abstract | In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted proteins known as the extracellular matrix. These cooperative interactions involve numerous cytokines acting through specific cell-surface receptors. When the balance between the cells and the extracellular matrix is perturbed, disease can result. This is clearly evident in the interactions mediated by the cytokine transforming growth factor-ß (TGF-ß). TGF-ß signaling has been studied extensively in fibrotic disease of lung, liver, skin, and kidney. However, little is known about the role of TGF-ß in bladder fibrosis. This review focuses on the mechanisms underlying TGF-ß expression and how it relates to fibrotic processes in bladder |
| Disciplines: | Biología |
| Keyword: | Biología celular, Fibrosis, Vejiga, Factor de crecimiento transformante, Colágena |
| Keyword: | Biology, Cell biology, Fibrosis, Bladder, Transforming growth factor, Collagen |
| Full text: | Texto completo (Ver PDF) |
