Transforming growth factor-beta signaling in bladder fibrosis

Título del documento: Transforming growth factor-beta signaling in bladder fibrosis
Revista: ARBS. Annual review of biomedical sciences
Base de datos: PERIÓDICA
Número de sistema: 000270163
ISSN: 1678-4618
Autores: 1
Instituciones: 1Vanderbilt University, Medical Center, Nashville, Tennessee. Estados Unidos de América
2Vanderbilt Children’s Hospital, Division of Pediatric Surgery, Nashville, Tennessee. Estados Unidos de América
Volumen: 10
Paginación: 1-5
País: Brasil
Idioma: Inglés
Tipo de documento: Revisión bibliográfica
Enfoque: Analítico
Resumen en inglés In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted proteins known as the extracellular matrix. These cooperative interactions involve numerous cytokines acting through specific cell-surface receptors. When the balance between the cells and the extracellular matrix is perturbed, disease can result. This is clearly evident in the interactions mediated by the cytokine transforming growth factor-ß (TGF-ß). TGF-ß signaling has been studied extensively in fibrotic disease of lung, liver, skin, and kidney. However, little is known about the role of TGF-ß in bladder fibrosis. This review focuses on the mechanisms underlying TGF-ß expression and how it relates to fibrotic processes in bladder
Disciplinas: Biología
Palabras clave: Biología celular,
Factor de crecimiento transformante,
Keyword: Biology,
Cell biology,
Transforming growth factor,
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