| Journal: | ARBS. Annual review of biomedical sciences |
| Database: | PERIÓDICA |
| System number: | 000351970 |
| ISSN: | 1678-4618 |
| Authors: | Heimann, Andrea1 Ferro, Emer2 |
| Institutions: | 1Proteimax Biotecnologia Ltda, Cotia, Sao Paulo. Brasil 2Universidade de Sao Paulo, Instituto de Ciencias Biomedicas, Sao Paulo. Brasil |
| Year: | 2009 |
| Volumen: | 11 |
| Pages: | 95-95T101 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | G protein-coupled receptors (GPCRs) represent the class of proteins with the highest impact from social, therapeutic and economic point of view. Today, more than 50% of drug targets are based on GPCRs and the annual worldwide sales exceeds 50 billion dollars. GPCRs are involved in all major diseases areas such as cardiovascular, metabolic, neurodegenerative, psychiatric, cancer and infectious diseases. The classical drug discovery process has relied on screening compounds, which interact favorably with the GPCR of interest followed by further chemical engineering as a mean of improving efficacy and selectivity. On the other hand, several new peptides with potential bioactivity are discovery every year. This review will focus on recent advancement on methods for identification of novel peptides with potential ability to activate GPCRs |
| Disciplines: | Biología |
| Keyword: | Biología celular, Bioquímica, Química farmacéutica, Proteínas G, Receptores de membrana, Desarrollo de fármacos, Transducción de señales |
| Keyword: | Biology, Cell biology, Biochemistry, Medicinal chemistry, G proteins, Membrane receptors, Drug development, Signal transduction |
| Full text: | Texto completo (Ver PDF) |
