New Approaches for G-protein Coupled Receptor Ligands Identification

Título del documento: New Approaches for G-protein Coupled Receptor Ligands Identification
Revista: ARBS. Annual review of biomedical sciences
Base de datos: PERIÓDICA
Número de sistema: 000351970
ISSN: 1678-4618
Autores: 1
Instituciones: 1Proteimax Biotecnologia Ltda, Cotia, Sao Paulo. Brasil
2Universidade de Sao Paulo, Instituto de Ciencias Biomedicas, Sao Paulo. Brasil
Volumen: 11
Paginación: 95-95T101
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés G protein-coupled receptors (GPCRs) represent the class of proteins with the highest impact from social, therapeutic and economic point of view. Today, more than 50% of drug targets are based on GPCRs and the annual worldwide sales exceeds 50 billion dollars. GPCRs are involved in all major diseases areas such as cardiovascular, metabolic, neurodegenerative, psychiatric, cancer and infectious diseases. The classical drug discovery process has relied on screening compounds, which interact favorably with the GPCR of interest followed by further chemical engineering as a mean of improving efficacy and selectivity. On the other hand, several new peptides with potential bioactivity are discovery every year. This review will focus on recent advancement on methods for identification of novel peptides with potential ability to activate GPCRs
Disciplinas: Biología
Palabras clave: Biología celular,
Química farmacéutica,
Proteínas G,
Receptores de membrana,
Desarrollo de fármacos,
Transducción de señales
Keyword: Biology,
Cell biology,
Medicinal chemistry,
G proteins,
Membrane receptors,
Drug development,
Signal transduction
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