| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000409088 |
| ISSN: | 1665-2681 |
| Authors: | Conti, Fabio1 Vitale, Giovanni1 Cursaro, Carmela1 Bernardi, Mauro1 Andreone, Pietro1 |
| Institutions: | 1Universita di Bologna, Dipartimento di Scienze Mediche e Chirurgiche, Bolonia, Emilia Romaña. Italia |
| Year: | 2016 |
| Volumen: | 15 |
| Number: | 2 |
| Pages: | 273-276 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, descriptivo |
| English abstract | Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor indicated for treatment of patients with chronic hepatitis B virus (CHB) and human immunodeficiency virus (HIV) infections. Despite the good safety profile of the drug, Fanconi syndrome is a possible adverse reaction of TDF treatment, especially in HIV-infected patients. Only a few cases have been reported in patients with CHB-monoinfections. This report presents a case of a 58-year-old man with mild HBeAg-negative CHB who was exposed to TDF and developed drug-induced Fanconi syndrome. Renal dysfunction reverted after TDF discontinuation and a switch to entecavir, and viral replication remained suppressed. A literature review yielded six additional cases of TDF-induced Fanconi syndrome, all with risk factors for renal dysfunction despite the patients having normal glomerular filtration rates. We discuss the overall risk for Fanconi syndrome in CHB-monoinfected patients exposed to TDF and the importance of careful monitoring of glomerular and tubular functions even when pre-existing kidney disease is not present |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Gastroenterología, Virus de la hepatitis B, Hepatitis crónica, Tenofovir, Efectos adversos, Toxicidad renal, Síndrome de Fanconi |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Hepatitis B virus, Chronic hepatitis, Tenofovir, Adverse effects, Renal toxicity, Fanconi syndrome |
| Full text: | Texto completo (Ver PDF) |
