Tenofovir-induced Fanconi syndrome in a patient with chronic hepatitis B monoinfection



Título del documento: Tenofovir-induced Fanconi syndrome in a patient with chronic hepatitis B monoinfection
Revue: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000409088
ISSN: 1665-2681
Autores: 1
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Instituciones: 1Universita di Bologna, Dipartimento di Scienze Mediche e Chirurgiche, Bolonia, Emilia Romaña. Italia
Año:
Volumen: 15
Número: 2
Paginación: 273-276
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico, descriptivo
Resumen en inglés Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor indicated for treatment of patients with chronic hepatitis B virus (CHB) and human immunodeficiency virus (HIV) infections. Despite the good safety profile of the drug, Fanconi syndrome is a possible adverse reaction of TDF treatment, especially in HIV-infected patients. Only a few cases have been reported in patients with CHB-monoinfections. This report presents a case of a 58-year-old man with mild HBeAg-negative CHB who was exposed to TDF and developed drug-induced Fanconi syndrome. Renal dysfunction reverted after TDF discontinuation and a switch to entecavir, and viral replication remained suppressed. A literature review yielded six additional cases of TDF-induced Fanconi syndrome, all with risk factors for renal dysfunction despite the patients having normal glomerular filtration rates. We discuss the overall risk for Fanconi syndrome in CHB-monoinfected patients exposed to TDF and the importance of careful monitoring of glomerular and tubular functions even when pre-existing kidney disease is not present
Disciplinas: Medicina
Palabras clave: Farmacología,
Gastroenterología,
Virus de la hepatitis B,
Hepatitis crónica,
Tenofovir,
Efectos adversos,
Toxicidad renal,
Síndrome de Fanconi
Keyword: Medicine,
Gastroenterology,
Pharmacology,
Hepatitis B virus,
Chronic hepatitis,
Tenofovir,
Adverse effects,
Renal toxicity,
Fanconi syndrome
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