| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000435792 |
| ISSN: | 0001-3765 |
| Authors: | Sette de Souza, Pedro Henrique1 Santana, Cleildo P. de2 Sousa, Ilza Maria O3 Foglio, Mary Ann3 Medeiros, Francinalva D. de4 Medeiros, Ana Cláudia D. de5 |
| Institutions: | 1Universidade de Pernambuco, Faculdade de Odontologia, Arcoverde, Pernambuco. Brasil 2Universidade Federal de Minas Gerais, Centro de Tecnologia em Desenvolvimento de Medicamentos, Belo Horizonte, Minas Gerais. Brasil 3Universidade de Campinas, Centro Pluridisciplinar de Pesquisas Quimicas, Paulinia, Sao Paulo. Brasil 4Universidade Federal de Campina Grande, Faculdade de Farmacia, Cuite, Paraiba. Brasil 5Universidade Estadual da Paraiba, Departamento de Ciencias Farmaceuticas, Campina Grande, Paraiba. Brasil |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 4 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Dental caries and periodontal disease are the most prevalent of the biofilm-dependent diseases. With numerous side effects on the use of chlorhexidine, the search for new safe therapeutic alternatives for microorganisms involved with these diseases increases every day. This study aimed to evaluate the antimicrobial activity and cytotoxicity of extracts made from the bark of Schinopsis brasiliensis Engl. against five oral microorganisms and analyze their phytochemical and thermal degradation profile. The liquid-liquid partition was performed with hexane, chloroform and ethyl acetate. The identification and quantification of the chemical marker was done. Antimicrobial activity was evaluated based on the minimum inhibitory concentration. The cytotoxicity was analyzed based on the hemolysing potential of the samples. The thermal degradation profile was performed by two different methods. Gallic acid was identified as the main compound of the samples and showed the highest amount in the chloroform fraction. All samples were able to inhibit the growth of the microorganisms tested and showed no cytotoxicity. The ethanol extract absorbs less heat than the fractions. All samples exhibited exothermic peak consistent with degradation of gallic acid. Based on the results, the samples used are potential candidates for use in dental formulations for biofilm control |
| Disciplines: | Medicina |
| Keyword: | Odontología, Caries, Enfermedad periodontal, Antibacterianos, Productos naturales, Schinopsis brasiliensis |
| Keyword: | Dentistry, Caries, Periodontal disease, Antibacterial agents, Natural products, Schinopsis brasiliensis |
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