Schinopsis brasiliensis Engl. to combat the biofilm-dependents diseases in vitro



Título del documento: Schinopsis brasiliensis Engl. to combat the biofilm-dependents diseases in vitro
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000435792
ISSN: 0001-3765
Autores: 1
2
3
3
4
5
Instituciones: 1Universidade de Pernambuco, Faculdade de Odontologia, Arcoverde, Pernambuco. Brasil
2Universidade Federal de Minas Gerais, Centro de Tecnologia em Desenvolvimento de Medicamentos, Belo Horizonte, Minas Gerais. Brasil
3Universidade de Campinas, Centro Pluridisciplinar de Pesquisas Quimicas, Paulinia, Sao Paulo. Brasil
4Universidade Federal de Campina Grande, Faculdade de Farmacia, Cuite, Paraiba. Brasil
5Universidade Estadual da Paraiba, Departamento de Ciencias Farmaceuticas, Campina Grande, Paraiba. Brasil
Año:
Volumen: 92
Número: 4
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Dental caries and periodontal disease are the most prevalent of the biofilm-dependent diseases. With numerous side effects on the use of chlorhexidine, the search for new safe therapeutic alternatives for microorganisms involved with these diseases increases every day. This study aimed to evaluate the antimicrobial activity and cytotoxicity of extracts made from the bark of Schinopsis brasiliensis Engl. against five oral microorganisms and analyze their phytochemical and thermal degradation profile. The liquid-liquid partition was performed with hexane, chloroform and ethyl acetate. The identification and quantification of the chemical marker was done. Antimicrobial activity was evaluated based on the minimum inhibitory concentration. The cytotoxicity was analyzed based on the hemolysing potential of the samples. The thermal degradation profile was performed by two different methods. Gallic acid was identified as the main compound of the samples and showed the highest amount in the chloroform fraction. All samples were able to inhibit the growth of the microorganisms tested and showed no cytotoxicity. The ethanol extract absorbs less heat than the fractions. All samples exhibited exothermic peak consistent with degradation of gallic acid. Based on the results, the samples used are potential candidates for use in dental formulations for biofilm control
Disciplinas: Medicina
Palabras clave: Odontología,
Caries,
Enfermedad periodontal,
Antibacterianos,
Productos naturales,
Schinopsis brasiliensis
Keyword: Dentistry,
Caries,
Periodontal disease,
Antibacterial agents,
Natural products,
Schinopsis brasiliensis
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