| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000436210 |
| ISSN: | 0001-3765 |
| Authors: | Dkhil, Mohamed A1 Diab, Marwa S.M3 Lokman, Maha S2 El Sayed, Heba2 Bauomy, Amira A2 Al Shaebi, Esam M1 Al Quraishy, Saleh1 |
| Institutions: | 1King Saud University, College of Science, Riyadh. Arabia Saudita 2Helwan University, Faculty of Science, El Cairo. Egipto 3National Organization For Drug Control and Research, Molecular Drug Evaluation Department, Giza. Egipto |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 1 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Cadmium, present in the environment, accumulates in different organs of animals and humans, and has deleterious effects on the kidney. In this study, we investigated the protective effects of the methanolic extract of Pleurotus ostreatus in comparison with silymarin on renal function in cadmium-intoxicated rats for five days. Rats intraperitoneally injected with cadmium chloride (1 mg/kg). These rats were treated with either P. ostreatus extract (200 mg/kg) or silymarin to investigate the protective effects of the extract. Cadmium treatment induced significant histopathological impairments and increased cadmium levels, DNA fragmentation, and renal oxidative stress. However, treatment with P. ostreatus extract or silymarin improved the pathology, reduced the level of cadmium in renal tissue, and restored DNA fragmentation. In addition, a significant reduction in lipid peroxidation and reactive oxygen species levels, and a significant increase in the levels of glutathione and catalase activity were observed. Thus, protective effects of P. ostreatus extract to its components. Chromatographic analysis of the P. ostreatus confirmed the presence of five phenolics (gallic acid, chlorogenic acid, catechin, propyl gallate, and cinnamic acid) that exhibit strong antioxidant properties as free radical scavengers. Therefore, our findings demonstrate that treatment with P. ostreatus extract protects against cadmium-induced nephrotoxicity in female rats |
| Disciplines: | Química |
| Keyword: | Farmacología, Hongos, Cadmio, Nefrotoxicidad, Efecto protector, Pleurotus ostreatus, Modelos animales |
| Keyword: | Pharmacology, Fungi, Nephrotoxicity, Cadmium, Protective effect, Pleurotus ostreatus, Animal models |
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