Nephroprotective effect of Pleurotus ostreatus extract against cadmium chloride toxicity in rats



Título del documento: Nephroprotective effect of Pleurotus ostreatus extract against cadmium chloride toxicity in rats
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000436210
ISSN: 0001-3765
Autores: 1
3
2
2
2
1
1
Instituciones: 1King Saud University, College of Science, Riyadh. Arabia Saudita
2Helwan University, Faculty of Science, El Cairo. Egipto
3National Organization For Drug Control and Research, Molecular Drug Evaluation Department, Giza. Egipto
Año:
Volumen: 92
Número: 1
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Cadmium, present in the environment, accumulates in different organs of animals and humans, and has deleterious effects on the kidney. In this study, we investigated the protective effects of the methanolic extract of Pleurotus ostreatus in comparison with silymarin on renal function in cadmium-intoxicated rats for five days. Rats intraperitoneally injected with cadmium chloride (1 mg/kg). These rats were treated with either P. ostreatus extract (200 mg/kg) or silymarin to investigate the protective effects of the extract. Cadmium treatment induced significant histopathological impairments and increased cadmium levels, DNA fragmentation, and renal oxidative stress. However, treatment with P. ostreatus extract or silymarin improved the pathology, reduced the level of cadmium in renal tissue, and restored DNA fragmentation. In addition, a significant reduction in lipid peroxidation and reactive oxygen species levels, and a significant increase in the levels of glutathione and catalase activity were observed. Thus, protective effects of P. ostreatus extract to its components. Chromatographic analysis of the P. ostreatus confirmed the presence of five phenolics (gallic acid, chlorogenic acid, catechin, propyl gallate, and cinnamic acid) that exhibit strong antioxidant properties as free radical scavengers. Therefore, our findings demonstrate that treatment with P. ostreatus extract protects against cadmium-induced nephrotoxicity in female rats
Disciplinas: Química
Palabras clave: Farmacología,
Hongos,
Cadmio,
Nefrotoxicidad,
Efecto protector,
Pleurotus ostreatus,
Modelos animales
Keyword: Pharmacology,
Fungi,
Nephrotoxicity,
Cadmium,
Protective effect,
Pleurotus ostreatus,
Animal models
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