Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats
Document title: Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000418016
ISSN: 0001-3765
Authors: 1
2
3
3
1
1
Institutions: 1Universidade de Caxias do Sul, Instituto de Biotecnologia, Caxias do Sul, Rio Grande do Sul. Brasil
2University of Toronto, Department of Psychiatry, Toronto, Ontario. Canadá
3Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul. Brasil
Year:
Season: Mar
Volumen: 89
Number: 1
Pages: 155-162
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases
Disciplines: Biología
Keyword: Fisiología animal,
Jugo de uva,
Polifenoles,
Neuroprotección,
Cerebro,
Ratas
Keyword: Animal physiology,
Grape juice,
Polyphenols,
Neuroprotection,
Brain,
Rats
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