Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats
Título del documento: Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000418016
ISSN: 0001-3765
Autors: 1
2
3
3
1
1
Institucions: 1Universidade de Caxias do Sul, Instituto de Biotecnologia, Caxias do Sul, Rio Grande do Sul. Brasil
2University of Toronto, Department of Psychiatry, Toronto, Ontario. Canadá
3Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul. Brasil
Any:
Període: Mar
Volum: 89
Número: 1
Paginació: 155-162
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases
Disciplines Biología
Paraules clau: Fisiología animal,
Jugo de uva,
Polifenoles,
Neuroprotección,
Cerebro,
Ratas
Keyword: Animal physiology,
Grape juice,
Polyphenols,
Neuroprotection,
Brain,
Rats
Text complet: Texto completo (Ver HTML)