| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000436009 |
| ISSN: | 0001-3765 |
| Authors: | Silva, Regildo M.G. da1 Figueiredo, Célia C.M1 Gomes, Amanda C1 Ferreira, Paulo C1 Granero, Filipe O1 Santiago, Patrícia S2 Silva, Luciana P3 |
| Institutions: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias e Letras de Assis, Assis, Sao Paulo. Brasil 2Universidade Estadual Paulista "Julio de Mesquita Filho", Campu de Registro, Registro, Sao Paulo. Brasil 3Fundacao Educacional do Municipio de Assis, Assis, Sao Paulo. Brasil |
| Year: | 2020 |
| Volumen: | 92 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | This study aimed to investigate antigenotoxicity and antioxidant potential of extract, fractions and vitexin from C. antisyphiliticus. Methanolic extract was fractionated through solvents of increasing polarity. The composition of extracts and fractions were evaluated through phytochemical screening. Micronucleus test was performed in mice to evaluate the antigenotoxicity. Antioxidant activity was measured using the assay 1,1-diphenyl-2-picrylhydrazyl (DPPH), iron ion chelating, thiobarbituric acid assay and nitric oxide scavenging. Treatment with extract, fractions and vitexin did not produce an increase in Micronucleus mean values. However, Micronucleus (MN) mean values decreased in relation to control. methanolic extract presented antioxidant potential for DPPH (81%), iron ion chelating (77.8%), Thiobarbituric Acid (TBARS) (32.49%) and Nitric Oxide (NO) (80.97%). Ethyl acetate fraction showed the highest antioxidant activity (65.46%). The vitexin showed a Inhibitory Concentration (IC50) of DPPH value smaller in relation to control. Vitexin flavonoid was detected by High Performance Liquid Chromatography (HPLC), infrared spectrometry and nuclear magnetic resonance. It can be inferred that methanolic extract, fraction ethyl acetate and vitexin isolated from C. antisyphiliticus is endowed with antigenotoxic and antioxidant potential |
| Disciplines: | Química, Biología |
| Keyword: | Fitoquímica, Angiospermas, Plantas medicinales, Compuestos fenólicos, Flavonoides, Antigenotoxicidad, Actividad antioxidante, Bioensayos, Ratones, Croton antisyphiliticus, Euphorbiaceae |
| Keyword: | Phytochemistry, Angiosperms, Medicinal plants, Phenolic compounds, Flavonoids, Antigenotoxicity, Antioxidant activity, Bioassays, Mice, Croton antisyphiliticus, Euphorbiaceae |
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