| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000436219 |
| ISSN: | 0001-3765 |
| Authors: | Ricarte, Lara P1 Bezerra, Gabrieli P1 Romero, Nirla R1 Silva, Horlando C. da2 Lemos, Telma L.G2 Arriaga, Angela M. C2 Alves, Péricles B3 Santos, Marcelo B. dos3 Militao, Gardenia C.G4 Silva, Thiago D.S4 Braz-Filho, Raimundo5 Santiago, Gilvandete M.P1 |
| Institutions: | 1Universidade Federal do Ceara, Faculdade de Farmacia, Fortaleza, Ceara. Brasil 2Universidade Federal do Ceara, Centro de Ciencias, Fortaleza, Ceara. Brasil 3Universidade Federal de Sergipe, Centro de Ciencias Exatas e Tecnologia, Sao Cristovao, Sergipe. Brasil 4Universidade Federal de Pernambuco, Centro de Ciencias Biologicas, Recife, Pernambuco. Brasil 5Universidade Estadual do Norte Fluminense, Setor de Quimica de Produtos Naturais, Campos dos Goytacazes, Rio de Janeiro. Brasil |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 1 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The essential oils obtained by hydrodistillation from fresh leaves of Vitex agnus-castus and Ocimum campechianum, and from fresh inflorescences of Ocimum carnosum were analysed by GC-FID and GC-MS. The major components of V. agnus-castus essential oil were identified as 1,8-cineole (47.9%), terpinyl α-acetate (11.6%), sabinene (11.2%) and caryophyllene oxide (9.7%), while in the O. campechianum essential oil were eugenol (72.1%), β-elemene (6.8%), (E)-caryophyllene (6.4%) and bicyclogermacrene (5.2%). Linalool (79.0%), α-epi-cadinol (5.4%), terpinen-4-ol (3.2%) and 1,8-cineole (2.8%) were the major constituents in the O. carnosum essential oil. The essential oils were subsequently evaluated for their larvicidal and cytotoxic activities. Larval bioassay against Aedes aegypti of V. agnus-castus, O. campechianum and O. carnosum essential oils showed LC50 values of 97.55 ± 0.35, 81.45 ± 0.35 and 109.49 ± 0.35 μg/mL, respectively. The in vitro cytotoxic activities of the essential oils has been evaluated on breast adenocarcinoma (MCF-7), lung carcinoma (NCI-H292), pro-myelocytic leukemia (HL-60), and cervical adenocarcinoma (HEP-2) human cell lines, and pro-myelocytic leukemia cells lines (HL-60) were found to be the most sensitive to all the essential oils tested than the others. This is the first report on larvicidal and cytotoxic activities of these essential oils |
| Disciplines: | Biología, Química |
| Keyword: | Fitoquímica, Aceites esenciales, Bioensayos, Actividad larvicida, Citotoxicidad, Vitex agnus-castus, Ocimum campechianum, Ocimum carnosum, Lamiaceae |
| Keyword: | Phytochemistry, Essential oils, Bioassays, Larvicidal activity, Cytotoxicity, Vitex agnus-castus, Ocimum campechianum, Ocimum carnosum, Lamiaceae |
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