Chemical composition and biological activities of the essential oils from Vitex-agnus castus, Ocimum campechianum and Ocimum carnosum



Título del documento: Chemical composition and biological activities of the essential oils from Vitex-agnus castus, Ocimum campechianum and Ocimum carnosum
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000436219
ISSN: 0001-3765
Autores: 1
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Instituciones: 1Universidade Federal do Ceara, Faculdade de Farmacia, Fortaleza, Ceara. Brasil
2Universidade Federal do Ceara, Centro de Ciencias, Fortaleza, Ceara. Brasil
3Universidade Federal de Sergipe, Centro de Ciencias Exatas e Tecnologia, Sao Cristovao, Sergipe. Brasil
4Universidade Federal de Pernambuco, Centro de Ciencias Biologicas, Recife, Pernambuco. Brasil
5Universidade Estadual do Norte Fluminense, Setor de Quimica de Produtos Naturais, Campos dos Goytacazes, Rio de Janeiro. Brasil
Año:
Volumen: 92
Número: 1
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés The essential oils obtained by hydrodistillation from fresh leaves of Vitex agnus-castus and Ocimum campechianum, and from fresh inflorescences of Ocimum carnosum were analysed by GC-FID and GC-MS. The major components of V. agnus-castus essential oil were identified as 1,8-cineole (47.9%), terpinyl α-acetate (11.6%), sabinene (11.2%) and caryophyllene oxide (9.7%), while in the O. campechianum essential oil were eugenol (72.1%), β-elemene (6.8%), (E)-caryophyllene (6.4%) and bicyclogermacrene (5.2%). Linalool (79.0%), α-epi-cadinol (5.4%), terpinen-4-ol (3.2%) and 1,8-cineole (2.8%) were the major constituents in the O. carnosum essential oil. The essential oils were subsequently evaluated for their larvicidal and cytotoxic activities. Larval bioassay against Aedes aegypti of V. agnus-castus, O. campechianum and O. carnosum essential oils showed LC50 values of 97.55 ± 0.35, 81.45 ± 0.35 and 109.49 ± 0.35 μg/mL, respectively. The in vitro cytotoxic activities of the essential oils has been evaluated on breast adenocarcinoma (MCF-7), lung carcinoma (NCI-H292), pro-myelocytic leukemia (HL-60), and cervical adenocarcinoma (HEP-2) human cell lines, and pro-myelocytic leukemia cells lines (HL-60) were found to be the most sensitive to all the essential oils tested than the others. This is the first report on larvicidal and cytotoxic activities of these essential oils
Disciplinas: Biología,
Química
Palabras clave: Fitoquímica,
Aceites esenciales,
Bioensayos,
Actividad larvicida,
Citotoxicidad,
Vitex agnus-castus,
Ocimum campechianum,
Ocimum carnosum,
Lamiaceae
Keyword: Phytochemistry,
Essential oils,
Bioassays,
Larvicidal activity,
Cytotoxicity,
Vitex agnus-castus,
Ocimum campechianum,
Ocimum carnosum,
Lamiaceae
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