| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000436005 |
| ISSN: | 0001-3765 |
| Authors: | Leite, Elma L1 Oliveira-Junior, Alberto F. de1 Carmo, Fillipe L.R. do2 Berkova, Nadia1 Barh, Debmalya3 Ghosh, Preetam4 Azevedo, Vasco2 |
| Institutions: | 1Institut National de la Recherche Agronomique, Rennes, Ille-et-Vilaine. Francia 2Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil 3Institute of Integrative Omics and Applied Biotechnology, Centre for Genomics and Applied Gene Technology, Purba Mednipur, West Bengal. India 4Virginia Commonwealth University, Department of Computer Science, Richmond, Virginia. Estados Unidos de América |
| Year: | 2020 |
| Volumen: | 92 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Staphylococcus aureus (S. aureus) is a highly versatile Gram-positive bacterium that is carried asymptomatically by up to 30% of healthy people, while being a major cause of healthcare-associated infections, making it a worldwide problem in clinical medicine. The adaptive evolution of S. aureus strains is demonstrated by its remarkable capacity to promptly develop high resistance to multiple antibiotics, thus limiting treatment choice. Nowadays, there is a continuous demand for an alternative to the use of antibiotics for S. aureus infections and a strategy to control the spread or to kill phylogenetically related strains. In this scenario, bacteriocins fit as with a promising and interesting alternative. These molecules are produced by a range of bacteria, defined as ribosomally synthesized peptides with bacteriostatic or bactericidal activity against a wide range of pathogens. This work reviews ascertained the main antibiotic-resistance mechanisms of S. aureus strains and the current, informative content concerning the applicability of the use of bacteriocins overlapping the use of conventional antibiotics in the context of S. aureus infections. Besides, we highlight the possible application of these biomolecules on an industrial scale in future work |
| Disciplines: | Medicina |
| Keyword: | Microbiología, Farmacología, Biotecnología, Bacteriocinas, Resistencia a antibióticos, Staphylococcus aureus |
| Keyword: | Microbiology, Pharmacology, Biotechnology, Staphylococcus aureus, Antibiotic resistance, Bacteriocins |
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