| Revue: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000453214 |
| ISSN: | 0034-8376 |
| Autores: | Manzo Merino, Joaquín1 Toro Arreola, Susana del2 Rocha Zavaleta, Leticia3 Peralta Zaragoza, Óscar5 Jiménez Lima, Roberto4 Madrid Marina, Vicente5 |
| Instituciones: | 1Instituto Nacional de Cancerología, Departamento de Investigación Básica, Ciudad de México. México 2Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco. México 3Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Ciudad de México. México 4Instituto Nacional de Cancerología, Departamento de Investigación Clínica, Ciudad de México. México 5Instituto Nacional de Salud Pública, Centro de Investigación en Enfermedades Infecciosas, Cuernavaca, Morelos. México |
| Año: | 2020 |
| Periodo: | Jul-Ago |
| Volumen: | 72 |
| Número: | 4 |
| Paginación: | 188-197 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Optimal function of the immune system allows the recognition and elimination of infected and tumor cells. However, these cells can develop mechanisms to evade the cellular immune response. In human papillomavirus (HPV) infection, dysregulation of major histocompatibility complex Class I molecules and other components of the innate immune system promote the survival of infected cells by allowing the infection to persist which, in turn, favors the development of cancer. Further, tumor cells possess inherent mechanisms designed to block the recognition and activation of cytotoxic lymphocytes: particularly, HPV proteins such as E1 and E2 and oncoproteins E5, E6, and E7 that inhibit immune mechanisms and/or stimulate the expression of immunosuppressive cytokines. These mechanisms include a decrease in receptor activation and costimulating molecules on the surface of immune cells, as well as the constitutive expression of molecules that inhibit their function, which allow HPV persistence and tumor progression. Immunotherapy-based therapeutic options are positioned as excellent candidates for the treatment of cervical cancer |
| Disciplinas: | Medicina |
| Palabras clave: | Oncología, Ginecología y obstetricia, Inmunología, Cáncer cervical, Virus del papiloma humano, Inmunoterapia, Linfocitos T citotóxicos, Muerte celular programada |
| Keyword: | Oncology, Gynecology and obstetrics, Immunology, Cervical cancer, Human papillomavirus, Cytotoxic T lymphocytes, Programmed cell death |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
